小(Xiao)儿(?)疾(Ji)病(Bing)中(Zhong)最(Zui)常(Chang)见(Jian)的(De)就(Jiu)是(Shi)肺(Fei)炎(Yan)了(Liao),(?)有(You)些(Xie)宝(Bao)宝(Bao)肺(Fei)炎(Yan)会(Hui)引(Yin)起(Qi)胸(Xiong)腔(Qiang)积(Ji)液(Ye)的(De)情(Qing)况(Kuang),(?)那(Na)么(Me)宝(Bao)宝(Bao)肺(Fei)炎(Yan)为(Wei)什(Shi)么(Me)会(Hui)出(Chu)现(Xian)胸(Xiong)腔(Qiang)积(Ji)液(Ye)呢(Ne)?(?)胸(Xiong)腔(Qiang)积(Ji)液(Ye)特(Te)点(Dian)有(You)哪(Na)些(Xie)呢(Ne)等(Deng)等(Deng)?带(Dai)着(Zhuo)这(Zhe)些(Xie)疑(Yi)问(Wen)一(Yi)起(Qi)来(Lai)看(Kan)看(Kan)吧(Ba)!(?)
儿(?)童(Tong)呼(Hu)吸(Xi)道(Dao)感(Gan)染(Ran)中(Zhong)一(Yi)类(Lei)常(Chang)见(Jian)的(De)病(Bing)原(Yuan)体(Ti)是(Shi)肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti),(?)并(Bing)且(Qie)在(Zai)下(Xia)呼(Hu)吸(Xi)道(Dao)感(Gan)染(Ran)中(Zhong)发(Fa)生(Sheng)率(Lu)最(Zui)高(Gao),(?)其(Qi)中(Zhong)重(Zhong)症(Zheng)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)的(De)比(Bi)例(Li)也(Ye)再(Zai)不(Bu)断(Duan)提(Ti)高(Gao),(?)支(Zhi)原(Yuan)体(Ti)常(Chang)引(Yin)起(Qi)大(Da)叶(Ye)性(Xing)肺(Fei)炎(Yan),(?)或(Huo)伴(Ban)有(You)肺(Fei)不(Bu)张(Zhang)以(Yi)及(Ji)胸(Xiong)腔(Qiang)积(Ji)液(Ye)的(De)患(Huan)儿(?),(?)在(Zai)临(Lin)床(Chuang)也(Ye)不(Bu)断(Duan)增(Zeng)加(Jia)。(?)
患(Huan)儿(?),(?)男(Nan) 13 岁(Sui),(?)咳(Ke)嗽(Sou),(?)发(Fa)热(Re)伴(Ban)胸(Xiong)痛(Tong) 2d
患(Huan)儿(?)于(Yu) 2d 前(Qian)无(Wu)明(Ming)显(Xian)诱(You)因(Yin)出(Chu)现(Xian)发(Fa)热(Re),(?)最(Zui)高(Gao)体(Ti)温(Wen)可(Ke)达(Da) 39℃(?),(?)无(Wu)寒(Han)战(Zhan)高(Gao)热(Re),(?)无(Wu)喘(Chuan)息(Xi)及(Ji)呼(Hu)吸(Xi)困(Kun)难(Nan),(?)无(Wu)恶(E)心(Xin)及(Ji)呕(Ou)吐(Tu),(?)初(Chu)为(Wei)干(Gan)咳(Ke),(?)自(Zi)诉(Su)有(You)痰(Tan)不(Bu)易(Yi)咳(Ke)出(Chu),(?)于(Yu)当(Dang)地(Di)门(Men)诊(Zhen)给(Gei)予(Yu)「(?)阿(A)莫(Mo)西(Xi)林(Lin)」(?)(具(Ju)体(Ti)量(Liang)不(Bu)详(Xiang))抗(Kang)感(Gan)染(Ran)对(Dui)症(Zheng)治(Zhi)疗(Liao),(?)效(Xiao)果(Guo)欠(Qian)佳(Jia),(?)今(Jin)晨(Chen)患(Huan)儿(?)咳(Ke)嗽(Sou)后(Hou)感(Gan)胸(Xiong)痛(Tong),(?)疼(Teng)痛(Tong)性(Xing)质(Zhi)为(Wei)钝(Dun)痛(Tong),(?)无(Wu)后(Hou)背(Bei)牵(Qian)涉(She)痛(Tong),(?)为(Wei)进(Jin)一(Yi)步(Bu)诊(Zhen)治(Zhi),(?)遂(Sui)入(Ru)院(Yuan)。(?)
入(Ru)院(Yuan)查(Cha)体(Ti):(?)神(Shen)清(Qing),(?)精(Jing)神(Shen)可(Ke),(?)热(Re)面(Mian)容(Rong),(?)咽(Yan)部(Bu)充(Chong)血(Xue),(?)双(Shuang)侧(Ce)扁(Bian)桃(Tao)体(Ti) I°(?) 肿(Zhong)大(Da),(?)双(Shuang)肺(Fei)呼(Hu)吸(Xi)音(Yin)粗(Cu),(?)可(Ke)闻(Wen)及(Ji)明(Ming)显(Xian)湿(Shi)音(Yin),(?)左(Zuo)下(Xia)肺(Fei)呼(Hu)吸(Xi)音(Yin)减(Jian)弱(Ruo),(?)心(Xin)音(Yin)低(Di)顿(Dun),(?)律(Lu)齐(Qi),(?)未(Wei)闻(Wen)及(Ji)明(Ming)显(Xian)杂(Za)音(Yin),(?)腹(Fu)软(Ruan),(?)未(Wei)触(Chu)及(Ji)明(Ming)显(Xian)包(Bao)块(Kuai),(?)神(Shen)经(Jing)系(Xi)统(Tong)查(Cha)体(Ti)未(Wei)见(Jian)异(Yi)常(Chang)。(?)
辅(Fu)助(Zhu)检(Jian)查(Cha):(?)白(Bai)细(Xi)胞(Bao):(?)5.9x10^9/L,(?)血(Xue)红(Hong)蛋(Dan)白(Bai) 134 g/L,(?)血(Xue)小(Xiao)板(Ban) 270x10^9/L,(?)中(Zhong)性(Xing)粒(Li)细(Xi)胞(Bao) 77%,(?)淋(Lin)巴(Ba)细(Xi)胞(Bao)比(Bi)率(Lu) 14.3%,(?)CRP:(?)12 mg/L,(?)LDH:(?)640IU/L,(?)CEA(-),(?)结(Jie)核(He)抗(Kang)体(Ti)(-),(?)肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti):(?)1:(?)160(+),(?)EBV-IgM(-)。(?)
1. 肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)为(Wei)什(Shi)么(Me)会(Hui)出(Chu)现(Xian)胸(Xiong)腔(Qiang)积(Ji)液(Ye)?
(1)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)主(Zhu)要(Yao)通(Tong)过(Guo)肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)的(De)直(Zhi)接(Jie)毒(Du)性(Xing)作(Zuo)用(Yong),(?)免(Mian)疫(Yi)反(Fan)应(Ying)损(Sun)害(Hai),(?)病(Bing)原(Yuan)菌(Jun)与(Yu)巨(Ju)细(Xi)胞(Bao)接(Jie)触(Chu)释(Shi)放(Fang)化(Hua)学(Xue)介(Jie)质(Zhi)的(De)毒(Du)性(Xing)和(He)炎(Yan)性(Xing)反(Fan)应(Ying)等(Deng)方(Fang)式(Shi)造(Zao)成(Cheng)上(Shang)呼(Hu)吸(Xi)道(Dao)黏(Nian)膜(Mo)上(Shang)皮(Pi)细(Xi)胞(Bao)损(Sun)害(Hai)致(Zhi)多(Duo)系(Xi)统(Tong)器(Qi)官(Guan)损(Sun)害(Hai)而(?)致(Zhi)病(Bing),(?)累(Lei)及(Ji)胸(Xiong)膜(Mo),(?)产(Chan)生(Sheng)胸(Xiong)膜(Mo)炎(Yan)症(Zheng),(?)引(Yin)起(Qi)渗(Shen)出(Chu)和(He)(或(Huo))免(Mian)疫(Yi)反(Fan)应(Ying)和(He)(或(Huo))受(Shou)损(Sun)的(De)细(Xi)胞(Bao)释(Shi)放(Fang)各(Ge)种(Zhong)酶(Mei)、(?)补(Bu)体(Ti)以(Yi)及(Ji)生(Sheng)物(Wu)活(Huo)性(Xing)物(Wu)质(Zhi)如(Ru)组(Zu)胺(An)等(Deng),(?)使(Shi)之(Zhi)胸(Xiong)膜(Mo)毛(Mao)细(Xi)血(Xue)管(Guan)通(Tong)透(Tou)性(Xing)增(Zeng)加(Jia),(?)促(Cu)使(Shi)胸(Xiong)腔(Qiang)积(Ji)液(Ye)形(Xing)成(Cheng);
(2)肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)会(Hui)诱(You)发(Fa)机(Ji)体(Ti)发(Fa)生(Sheng)免(Mian)疫(Yi)炎(Yan)性(Xing)反(Fan)应(Ying),(?)毛(Mao)细(Xi)气(Qi)管(Guan)上(Shang)皮(Pi)细(Xi)胞(Bao)严(Yan)重(Zhong)破(Po)坏(Huai),(?)在(Zai)修(Xiu)复(Fu)过(Guo)程(Cheng)中(Zhong)产(Chan)生(Sheng)大(Da)量(Liang)肉(Rou)芽(Ya)组(Zu)织(Zhi)以(Yi)及(Ji)炎(Yan)性(Xing)细(Xi)胞(Bao)的(De)浸(Jin)润(Run)、(?)肺(Fei)泡(Pao)灌(Guan)注(Zhu)液(Ye)中(Zhong)的(De)细(Xi)胞(Bao)因(Yin)子(Zi)明(Ming)显(Xian)增(Zeng)高(Gao)。(?)
2. 肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)合(He)并(Bing)胸(Xiong)腔(Qiang)积(Ji)液(Ye)特(Te)点(Dian)有(You)哪(Na)些(Xie)?
(1)高(Gao)热(Re)持(Chi)续(Xu)时(Shi)间(Jian)较(Jiao)长(Chang)
(2)咳(Ke)嗽(Sou)在(Zai)较(Jiao)晚(Wan)时(Shi)间(Jian)出(Chu)现(Xian)(一(Yi)般(Ban)在(Zai)发(Fa)病(Bing) 3d 后(Hou)开(Kai)始(Shi)),(?)症(Zheng)状(Zhuang)与(Yu)肺(Fei)部(Bu)体(Ti)征(Zheng)不(Bu)平(Ping)衡(Heng)(体(Ti)征(Zheng)发(Fa)病(Bing) 7d 左(Zuo)右(You)出(Chu)现(Xian));
(3)部(Bu)分(Fen)患(Huan)儿(?)会(Hui)出(Chu)现(Xian)胸(Xiong)痛(Tong)
(4)胸(Xiong)腔(Qiang)积(Ji)液(Ye)与(Yu)肺(Fei)部(Bu)炎(Yan)症(Zheng)同(Tong)侧(Ce),(?)以(Yi)单(Dan)侧(Ce)多(Duo)见(Jian),(?)可(Ke)呈(Cheng)包(Bao)裹(Guo)性(Xing),(?)多(Duo)数(Shu)为(Wei)少(Shao)至(Zhi)中(Zhong)量(Liang)胸(Xiong)腔(Qiang)积(Ji)液(Ye),(?)少(Shao)数(Shu)可(Ke)见(Jian)大(Da)量(Liang)或(Huo)双(Shuang)侧(Ce)胸(Xiong)腔(Qiang)积(Ji)液(Ye),(?)少(Shao)量(Liang)胸(Xiong)腔(Qiang)积(Ji)液(Ye)时(Shi)胸(Xiong)部(Bu)体(Ti)征(Zheng)不(Bu)明(Ming)显(Xian)。(?)
3. 实(Shi)验(Yan)室(Shi)指(Zhi)标(Biao)在(Zai)肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)中(Zhong)的(De)临(Lin)床(Chuang)意(Yi)义(Yi)
(1)乳(Ru)酸(Suan)脱(Tuo)氢(Qing)酶(Mei):(?)LDH 可(Ke)作(Zuo)为(Wei)判(Pan)断(Duan)肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)的(De)严(Yan)重(Zhong)程(Cheng)度(Du)和(He)预(Yu)后(Hou)的(De)一(Yi)个(Ge)可(Ke)靠(Kao)指(Zhi)标(Biao),(?)因(Yin)肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)伴(Ban)有(You)免(Mian)疫(Yi)反(Fan)应(Ying),(?)而(?)且(Qie)肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)与(Yu)机(Ji)体(Ti)的(De)很(Hen)多(Duo)器(Qi)官(Guan)都(Du)有(You)共(Gong)同(Tong)抗(Kang)原(Yuan),(?)因(Yin)此(Ci)在(Zai)机(Ji)体(Ti)感(Gan)染(Ran)肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)后(Hou),(?)便(Bian)会(Hui)随(Sui)之(Zhi)出(Chu)现(Xian)相(Xiang)应(Ying)的(De)自(Zi)身(Shen)抗(Kang)体(Ti);
(2)LDH 水(Shui)平(Ping)是(Shi)评(Ping)价(Jia)肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)疗(Liao)效(Xiao)的(De)有(You)效(Xiao)指(Zhi)标(Biao),(?)亦(Yi)在(Zai)临(Lin)床(Chuang)指(Zhi)导(Dao)中(Zhong),(?)如(Ru) LDH ≥(?) 364 时(Shi),(?)是(Shi)静(Jing)脉(Mai)使(Shi)用(Yong)激(Ji)素(Su)的(De)一(Yi)个(Ge)重(Zhong)要(Yao)指(Zhi)标(Biao)。(?)
(3)IL-8:(?)在(Zai) IL-8 的(De)趋(Qu)化(Hua)下(Xia)可(Ke)加(Jia)速(Su)中(Zhong)性(Xing)粒(Li)细(Xi)胞(Bao)、(?)嗜(Shi)碱(Jian)性(Xing)粒(Li)细(Xi)胞(Bao)、(?)T 淋(Lin)巴(Ba)细(Xi)胞(Bao)等(Deng)在(Zai)组(Zu)织(Zhi)内(Nei)的(De)浸(Jin)润(Run)、(?)聚(Ju)集(Ji),(?)造(Zao)成(Cheng)组(Zu)织(Zhi)损(Sun)伤(Shang)和(He)炎(Yan)症(Zheng)反(Fan)应(Ying),(?)当(Dang)并(Bing)发(Fa)胸(Xiong)腔(Qiang)积(Ji)液(Ye)的(De)肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)患(Huan)儿(?)的(De)胸(Xiong)膜(Mo)渗(Shen)出(Chu)液(Ye)中(Zhong)科(Ke)检(Jian)测(Ce)到(Dao)较(Jiao)高(Gao)水(Shui)平(Ping)的(De) IL-8。(?)
4. 肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)影(Ying)像(Xiang)学(Xue)表(Biao)现(Xian)有(You)哪(Na)些(Xie)特(Te)点(Dian)?
儿(?)童(Tong)肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)影(Ying)像(Xiang)学(Xue)表(Biao)现(Xian)较(Jiao)为(Wei)多(Duo)样(Yang)且(Qie)无(Wu)特(Te)异(Yi)性(Xing),(?)可(Ke)表(Biao)现(Xian)为(Wei)肺(Fei)门(Men)影(Ying)增(Zeng)浓(Nong)、(?)间(Jian)质(Zhi)性(Xing)肺(Fei)炎(Yan)、(?)支(Zhi)气(Qi)管(Guan)肺(Fei)炎(Yan);
(1)婴(Ying)幼(You)儿(?)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)多(Duo)见(Jian)斑(Ban)片(Pian)影(Ying)、(?)片(Pian)状(Zhuang)密(Mi)度(Du)增(Zeng)高(Gao)影(Ying)或(Huo)间(Jian)质(Zhi)性(Xing)病(Bing)变(Bian),(?)双(Shuang)肺(Fei)均(Jun)可(Ke)受(Shou)累(Lei),(?)部(Bu)分(Fen)重(Zhong)症(Zheng)患(Huan)儿(?)可(Ke)出(Chu)现(Xian)支(Zhi)气(Qi)管(Guan)扩(Kuo)张(Zhang)和(He)闭(Bi)塞(Sai)性(Xing)支(Zhi)气(Qi)管(Guan)炎(Yan)改(Gai)变(Bian);
(2)学(Xue)龄(Ling)前(Qian)及(Ji)学(Xue)龄(Ling)儿(?)童(Tong)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)主(Zhu)要(Yao)表(Biao)现(Xian)为(Wei)肺(Fei)段(Duan)或(Huo)肺(Fei)叶(Ye)的(De)实(Shi)变(Bian)影(Ying),(?)且(Qie)以(Yi)单(Dan)侧(Ce)受(Shou)累(Lei)为(Wei)主(Zhu),(?)与(Yu)年(Nian)长(Chang)儿(?)支(Zhi)原(Yuan)体(Ti)感(Gan)染(Ran)后(Hou)机(Ji)体(Ti)全(Quan)身(Shen)炎(Yan)症(Zheng)反(Fan)应(Ying)强(Qiang)烈(Lie)有(You)关(Guan),(?)可(Ke)伴(Ban)有(You)胸(Xiong)腔(Qiang)积(Ji)液(Ye)
5. 肺(Fei)炎(Yan)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)合(He)并(Bing)胸(Xiong)腔(Qiang)积(Ji)液(Ye)如(Ru)何(He)治(Zhi)疗(Liao)?
(1)抗(Kang)微(Wei)生(Sheng)物(Wu)治(Zhi)疗(Liao):(?)支(Zhi)原(Yuan)体(Ti)无(Wu)细(Xi)胞(Bao)壁(Bi),(?)故(Gu)应(Ying)选(Xuan)择(Ze)能(Neng)干(Gan)扰(Rao)和(He)抑(Yi)制(Zhi)微(Wei)生(Sheng)物(Wu)蛋(Dan)白(Bai)合(He)成(Cheng)的(De)药(Yao)物(Wu)。(?)由(You)于(Yu)四(Si)环(Huan)素(Su)类(Lei)和(He)喹(Kui)诺(Nuo)酮(Tong)类(Lei)药(Yao)物(Wu)在(Zai)牙(Ya)齿(Chi)和(He)骨(Gu)骼(Ge)发(Fa)育(Yu)方(Fang)面(Mian)有(You)很(Hen)大(Da)的(De)副(Fu)作(Zuo)用(Yong),(?)大(Da)环(Huan)内(Nei)酯(Zhi)类(Lei)抗(Kang)生(Sheng)素(Su)仍(Reng)是(Shi)在(Zai)儿(?)童(Tong)支(Zhi)原(Yuan)体(Ti)感(Gan)染(Ran)的(De)首(Shou)选(Xuan)用(Yong)药(Yao)。(?)
包(Bao)括(Kuo)阿(A)奇(Qi)霉(Mei)素(Su)、(?)红(Hong)霉(Mei)素(Su)等(Deng);支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)合(He)并(Bing)胸(Xiong)腔(Qiang)积(Ji)液(Ye)治(Zhi)疗(Liao)的(De)疗(Liao)程(Cheng)为(Wei) 2~(?)3 周(Zhou),(?)个(Ge)别(Bie)应(Ying)根(Gen)据(Ju)具(Ju)体(Ti)病(Bing)情(Qing)而(?)定(Ding)。(?)
(2)糖(Tang)皮(Pi)质(Zhi)激(Ji)素(Su)治(Zhi)疗(Liao):(?)轻(Qing)度(Du)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)合(He)并(Bing)胸(Xiong)腔(Qiang)积(Ji)液(Ye)不(Bu)需(Xu)要(Yao)使(Shi)用(Yong)糖(Tang)皮(Pi)质(Zhi)激(Ji)素(Su),(?)经(Jing)抗(Kang)生(Sheng)素(Su)治(Zhi)疗(Liao)后(Hou)积(Ji)液(Ye)可(Ke)自(Zi)行(Xing)吸(Xi)收(Shou)。(?)
如(Ru)重(Zhong)症(Zheng)支(Zhi)原(Yuan)体(Ti)肺(Fei)炎(Yan)合(He)并(Bing)胸(Xiong)腔(Qiang)积(Ji)液(Ye),(?)感(Gan)染(Ran)较(Jiao)重(Zhong)并(Bing)出(Chu)现(Xian)的(De)全(Quan)身(Shen)炎(Yan)性(Xing)反(Fan)应(Ying)综(Zong)合(He)征(Zheng)时(Shi),(?)可(Ke)使(Shi)用(Yong)糖(Tang)皮(Pi)质(Zhi)激(Ji)素(Su),(?)疗(Liao)程(Cheng)约(Yue) 10~(?)14d,(?)初(Chu)始(Shi)剂(Ji)量(Liang)甲(Jia)强(Qiang)龙(Long) 1~(?)2 mg/kg/d(5~(?)7d),(?)之(Zhi)后(Hou)逐(Zhu)渐(Jian)减(Jian)量(Liang)至(Zhi)停(Ting)药(Yao)(停(Ting)药(Yao)依(Yi)病(Bing)情(Qing)恢(Hui)复(Fu)程(Cheng)度(Du)而(?)定(Ding))。(?)
(3)外(Wai)科(Ke)治(Zhi)疗(Liao)。(?)
发(Fa)表(Biao)评(Ping)论(Lun)